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Products Details
Product Description
– EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM and 14.25 nM, respectively. EGFR-IN-46 is a potent anti-cancer agent. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis[1].
Web ID
– HY-144794
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H32F3N3O3
References
– [1]Elbadawi MM, et al. 2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights. J Enzyme Inhib Med Chem. 2022 Dec;37(1):349-372.
CAS Number
– 2764772-88-3
Molecular Weight
– 503.56
SMILES
– COC1=C(C=C2C(N=C(C=C2OCCCNC3CCN(CC3)C)C4=CC=C(C=C4)C(F)(F)F)=C1)OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;EGFR;FAK
Isoform
– EGFR/ErbB1/HER1
Pathway
– Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
