Download Files:
Products Details
Product Description
– EGFR-IN-3 (Compound 4c) is a potent EGFR inhibitor with an IC50 of 0.32 µM against EGFRwt-TK. EGFR-IN-3 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].
Web ID
– HY-144760
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H18F4N6O2S
References
– [1]Yan L, et al. Design, synthesis and biological evaluation of a series of dianilinopyrimidines as EGFR inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):832-843.
Molecular Weight
– 530.50
SMILES
– O=C(C1=C(NC2=NC(NC3=CC=C(NC(C4=CC=CC(F)=C4)=O)C=C3)=NC=C2C(F)(F)F)SC=C1)NC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
