EGFR-IN-12
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EGFR-IN-12

SKU T5168-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 120 CAD through 3,392 CAD

Products Details

Product Description

– EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.

Web ID

– T5168

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H18F3N5O

Citations

– 1. He X Y, Yang Y S, Zheng Y X, et al.Scutellarin combined with lidocaine exerts antineoplastic effect in human glioma associated with repression of epidermal growth factor receptor signaling.PloS one.2025, 20(1): e0318031.

References

– Zhang Q, et al. Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. J Am Chem Soc. 2006 Feb 22;128(7):2182-3.

CAS Number

– 879127-07-8

Molecular Weight

– C21H18F3N5O

Compound Purity

– 0.983

SMILES

– FC(F)(F)c1cccc(Nc2cc(Nc3cccc(NC(=O)C4CC4)c3)ncn2)c1

Pathway

– Tyrosine Kinase/Adaptors|||Angiogenesis|||Apoptosis|||JAK/STAT signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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