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Products Details
Product Description
– EGFR/HER2/TS-IN-1 (Compound 4d) is an EGFR, HER2 and TS (Thymidylate synthase) inhibitor with IC50 values of 0.203, 0.088 and 0.168 μM against EGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cell apoptosis[1].
Web ID
– HY-146238
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H15N5O4S2
References
– [1]Abdellatif KRA, et al. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorg Chem. 2020 Aug;101:103976.
CAS Number
– 2444363-11-3
Molecular Weight
– 501.54
SMILES
– N#CC1=C(C2=COC3=C(C2=O)C=CC=C3)NC(SCC(NC4=NC5=C(S4)C=C(C)C=C5)=O)=NC1=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;EGFR;Thymidylate Synthase
Isoform
– EGFR/ErbB1/HER1;ErbB2/HER2
Pathway
– Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
