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Products Details
Product Description
– EGFR/HER2-IN-7 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2-IN-7 is a EGFR/HER2 kinase and DHFR inhibitor, with IC50s of 0.18 μM (EGFR), 0.146 μM (HER2), respectively. EGFR/HER2-IN-7 shows moderate inhibition on DHFR (IC50=0.907 μM)[1].
Web ID
– HY-151158
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H21N3O2S
References
– [1]Sabry MA, et al. New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity. Eur J Med Chem. 2022 Aug 10;241:114661.Â
CAS Number
– 2820126-28-9
Molecular Weight
– 355.45
SMILES
– O=C(C1=CSC2=NC(CN3CCCCC3)=C(C4=CC=C(C)C=C4)N21)O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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