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Products Details
Product Description
– EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual inhibitor of EGFR and HER2 with IC50 values of 5.02 µM and 0.83 µM against EGFR and HER2, respectively[1].
Web ID
– HY-115951
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H23N5O3
References
– [1]Sangande, et al. 2-substituted 4-aminoquinazoline derivatives as potential dual inhibitors of EGFR and HER2: an in silico and in vitro study. Medicinal Chemistry Research 31.5 (2022): 762-771.
CAS Number
– 1215571-02-0
Molecular Weight
– 453.49
SMILES
– COC1=CC=C(C2=NN=C(C3=NC(NCC4=CC=CC=C4OCC)=C5C=CC=CC5=N3)O2)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1;ErbB2/HER2
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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