EG-011

SKU HY-148683-10 mg Category Tags , ,

$180$1,450

Products Details

Product Description

– EG-011 is the first-in-class and potent Wiskott-Aldrich syndrome protein (WASP) activator. EG-011 activates the auto-inhibited form of WASP with strong actin polymerization. EG-011 has selective anti-tumor activity in lymphomas[1][2][3].

Web ID

– HY-148683

Storage Temperature

– -20°C, 3 years (Powder)

Shipping

– Blue Ice

Molecular Formula

– C28H26N4O4

References

– [1]E. Gaudio, et al. EG-011 IS A NOVEL SMALL MOLECULE WITH IN VITRO AND IN VIVOANTI-TUMOR ACTIVITY AGAINST LYMPHOMA. Hematological OncologyVolume 37: 15th International Conference on Malignant Lymphoma Palazzo dei Congressi, Lugano, Switzerland, 18-22 June, 2019.|[2]Filippo Spriano, et al. Abstract 1817: EG-011 is a first-in-class Wiskott-Aldrich syndrome protein (WASp) activator with anti-tumor activity. Cancer Res (2022) 82 (12_Supplement): 1817. |[3]F. Spriano, et al. The first-in-class WASP activator EG-011 is active in lymphoma and multiple myeloma cell lines resistant to FDA approved compounds. European Journal of Cancer 174S1 (2022) S3-S128.

CAS Number

– 2377113-41-0

Molecular Weight

– 482.53

Compound Purity

– 98.77

SMILES

– O=C(N1CCCC(C1)N2C(C3=NC=CC=C3N(CC4=CC=C(C=C4)OC5=CC=CC=C5)C2=O)=O)C=C

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 125 mg/mL (ultrasonic)

Target

– Arp2/3 Complex

Pathway

– Cytoskeleton

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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