(E/Z)-Teriflunomide

$32$90

Products Details

Product Description

– (E/Z)-Teriflunomide ((E/Z)-A77 1726) is the active metabolite of Leflunomide (HY-B0083). Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Leflunomide can be used for the research of rheumatoid arthritis (RA)[1].

Web ID

– HY-110159

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C12H9F3N2O2

References

– [1]R I Fox, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93(3):198-208.

CAS Number

– 108605-62-5

Molecular Weight

– 270.21

Compound Purity

– 99.86

SMILES

– C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O

Clinical Information

– Launched

Research Area

– Infection; Inflammation/Immunology

Solubility

– DMSO : 50 mg/mL (ultrasonic)

Target

– Dihydroorotate Dehydrogenase

Pathway

– Metabolic Enzyme/Protease

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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