(E/Z)-Necrosulfonamide
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(E/Z)-Necrosulfonamide

SKU T7129-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 53 CAD through 493 CAD

Products Details

Product Description

– (E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.

Web ID

– T7129

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H15N5O6S2

Citations

– 1. Ouyang S, Li H, Lou L, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biology. 2022: 102317 2. Yi Y, Gao K, Zhang L, et al. Zearalenone Induces MLKL-Dependent Necroptosis in Goat Endometrial Stromal Cells via the Calcium Overload/ROS Pathway. International Journal of Molecular Sciences. 2022, 23(17): 10170. 3. Sun Y, He L, Wang T, et al. Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells. Molecular Neurobiology. 2020, 57(11): 4628-4641. 4. Yi Y, Gao K, Lin P, et al. Staphylococcus aureus-Induced Necroptosis Promotes Mitochondrial Damage in Goat Endometrial Epithelial Cells. Animals. 2022, 12(17): 2218. 5. Bi G, Liang J, Shan G, et al.Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells.Cancer Research.2023: CAN-22-3977. 6. Li Y, Hu G, Huang F, et al.MAT1A Suppression by the CTBP1/HDAC1/HDAC2 Transcriptional Complex Induces Immune Escape and Reduces Ferroptosis in Hepatocellular Carcinoma.Laboratory Investigation.2023, 103(8): 100180. 7. Chen C, Cheng Y, Lei H, et al.SHP2 potentiates anti-PD-1 effectiveness through intervening cell pyroptosis resistance in triple-negative breast cancer.Biomedicine & Pharmacotherapy.2023, 168: 115797. 8. Bi G, Liang J, Bian Y, et al.Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer.Nature Communications.2024, 15(1): 2461.

References

– Wang Y , Wang J , Wang H , et al. Necrosulfonamide Attenuates the Spinal Cord Injury Via Necroptosis Inhibition[J]. World Neurosurgery, 2018:S1878875018306569.

CAS Number

– 432531-71-0

Molecular Weight

– C18H15N5O6S2

Compound Purity

– 0.9762

SMILES

– COc1nccnc1NS(=O)(=O)c1ccc(NC(=O)C=Cc2ccc(s2)[N+]([O-])=O)cc1

Pathway

– MAPK

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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