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Products Details
Product Description
– Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].
Web ID
– HY-12455
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H25N3O8
References
– [1]Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96.
CAS Number
– 118292-34-5
Molecular Weight
– 507.49
SMILES
– O=C([C@@](N1)(C)C(C([C@@]23[C@@](C3)([H])CN(C(C(N4)=CC5=C4C(OC)=C(OC)C(OC)=C5)=O)C2=C6)=C1C6=O)=O)OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ADC Cytotoxin;Apoptosis;Caspase
Isoform
– Caspase 3;Caspase 9;Duocarmycins
Pathway
– Antibody-drug Conjugate/ADC Related;Apoptosis
Product type
– ADC Related
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