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DPN
Price range: 51 CAD through 563 CAD
Products Details
Product Description
– DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .
Web ID
– T7644
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C15H13NO2
Citations
– 1. Lu Z, Cao Y, Zhang D, et al. Discovery of Thieno [2, 3-e] indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability. Journal of Medicinal Chemistry. 2022
2. Tong H, Fan S, Hu W, et al.Diarylpropionitrile-stimulated ERβ nuclear accumulation promotes MyoD-induced muscle regeneration in mdx mice by interacting with FOXO3A.Pharmacological Research.2024: 107376.
3. Zhang D, Lu Z, He Y, et al.Discovery of Thiochroman Derivatives as Potent, Oral Selective Estrogen Receptor Degraders and Antagonists for the Treatment of Endocrine-Resistant Breast Cancer.Journal of Medicinal Chemistry.2024
References
– Marvin, J, Meyers, et al. Estrogen Receptor-β Potency-Selective Ligands: Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues[J]. Journal of Medicinal Chemistry, 2001.
CAS Number
– 1428-67-7
Molecular Weight
– C15H13NO2
Compound Purity
– 0.9901
SMILES
– Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1
Pathway
– Autophagy|||Endocrinology/Hormones|||Apoptosis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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