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Donepezil
$38 – $222
Products Details
Product Description
– Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].
Web ID
– HY-14566
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C24H29NO3
Citations
– Comput Struct Biotec. 2023 Feb 24.|Foods. 2022, 11(14), 2095.|Journal of Pharmaceutical Investigation. 2021 Mar 31.|Clin Transl Med. 2021 May 28.|J Integr Neurosci. 2023 May 16, 22(3), 76.|Patent. US20210378961A1.
References
– [1]Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13.|[2]Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38(1): p. 181-93.|[3]Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18(2): p. 185-7.
CAS Number
– 120014-06-4
Molecular Weight
– 379.49
Compound Purity
– 99.91
SMILES
– O=C(C(C=C(OC)C(OC)=C1)=C1C2)C2CC(CC3)CCN3CC4=CC=CC=C4
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)|H2O : 2 mg/mL (ultrasonic;warming;heat to 80°C)
Target
– Cholinesterase (ChE)
Isoform
– AChE
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
