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Dolastatin 10
$300 – $800
Products Details
Product Description
– Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.
Web ID
– HY-15580
Storage Temperature
– -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C42H68N6O6S
References
– [1]Brentuximab vedotin. Drugs R D. 2011;11(1):85-95.|[2]Pettit GR, et al. Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications ofdolastatin 10. J Nat Prod. 2011 May 27;74(5):962-8.|[3]Pitot HC, et al. Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors. Clin Cancer Res. 1999 Mar;5(3):525-31.
CAS Number
– 110417-88-4
Molecular Weight
– 785.09
Compound Purity
– 98.63
SMILES
– O=C([C@H](C)[C@H]([C@]1([H])CCCN1C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@H](NC([C@@H](N(C)C)C(C)C)=O)C(C)C)=O)C)=O)OC)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : ≥ 100 mg/mL
Target
– ADC Cytotoxin;Microtubule/Tubulin
Isoform
– Auristatin
Pathway
– Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
