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Products Details
Product Description
– DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy. DIZ-3 intercalates into the G4-G4 interface, stabilizing the higher-order structure. DIZ-3 induces cell cycle arrest and apoptosis, and thus inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cells[1].
Web ID
– HY-146812
Shipping
– Room temperature
Molecular Formula
– C46H44F2N8
References
– [1]Ming-Hao Hu, et al. Dimeric aryl-substituted imidazoles may inhibit ALT cancer by targeting the multimeric G-quadruplex in telomere. Eur J Med Chem. 2020 Jan 15;186:111891.
CAS Number
– 2675490-72-7
Molecular Weight
– 746.89
SMILES
– CN1CCN(CC1)C2=CC=C(C=C2)C3=C(NC(C4=CC=C(C=C4)C5=NC(C6=CC=C(C=C6)F)=C(N5)C7=CC=C(C=C7)N8CCN(CC8)C)=N3)C9=CC=C(C=C9)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– G-quadruplex
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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