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Products Details
Product Description
– Dihydro-5-azacytidine acetate (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine acetate has an antitumor activity[1][2].
Web ID
– HY-106689A
Shipping
– Room temperature
Molecular Formula
– C10H18N4O7
References
– [1]Robert A Kratzke, et al. Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia group B 159904. J Thorac Oncol. 2008 Apr;3(4):417-21.|[2]W C Powell, et al. Biochemical pharmacology of 5,6-dihydro-5-azacytidine (DHAC) and DNA hypomethylation in tumor (L1210)-bearing mice. Cancer Chemother Pharmacol. 1988;21(2):117-21.
CAS Number
– 2470972-18-8
Molecular Weight
– 306.27
SMILES
– NC(NC1)=NC(N1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)=O.CC(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DNA Methyltransferase;Nucleoside Antimetabolite/Analog
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Oligonucleotides
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