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Product Description
– Dicyclomine (Dicycloverine) is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine (Dicycloverine) shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2].
Web ID
– HY-B1339A
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C19H35NO2
References
– [1]Antonella Caccamo, et al. Â M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49(5):671-82.doi: 10.1016/j.neuron.2006.01.020. |[2]Antonella Caccamo, et al. Â M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49(5):671-82.doi: 10.1016/j.neuron.2006.01.020. |[3]Susan J Bartko,et al. A Computer-Automated Touchscreen Paired-Associates Learning (PAL) Task for Mice: Impairments Following Administration of Scopolamine or Dicyclomine and Improvements Following Donepezil.Psychopharmacology (Berl). 2011 Mar;214(2):537-48.
CAS Number
– 77-19-0
Molecular Weight
– 309.49
SMILES
– O=C(C1(C2CCCCC2)CCCCC1)OCCN(CC)CC
Clinical Information
– Launched
Solubility
– 10 mM in DMSO
Target
– mAChR
Isoform
– mAChR1;mAChR2
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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