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Products Details
Product Description
– DIBA-Cy5 is a fluorescent DIBA antagonist made up be DIBA-alkyne binding Cyanine5 fluorophores (Cy5) and polyethylene glycol (PEG) biomolecules. DIBA-Cy5 can serve as a fluorescent ligand, suitable for probe attachment through click chemistry. DIBA-Cy5 exerts a high binding affinity to type-2 mAChR (M2R) with the Kd value of 1.80 nM, can directly stain M2R receptors in the sinoatrial node of a mouse heart[1].
Web ID
– HY-151801
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C69H89N11O12S3
References
– [1]Yang H, et al. Click Chemistry-Enabled Conjugation Strategy for Producing Dibenzodiazepinone-Type Fluorescent Probes To Target M2 Acetylcholine Receptors. Bioconjug Chem. 2022 Nov 3.
Molecular Weight
– 1360.71
SMILES
– CC1(C2=CC(S(=O)([O-])=O)=CC=C2[N+](CCCCCC(NCCCN3C=C(N=N3)CCN4CCN(CC4)CCCCC5CCN(CC5)CC(N6C7=CC=CC=C7NC(C8=C6C=CC=C8)=O)=O)=O)=C1/C=C/C=C/C=C9N(C%10=C(C/9(C)C)C=C(C=C%10)S(=O)(O)=O)CCCS(=O)(O)=O)C
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– mAChR
Isoform
– mAChR1;mAChR2
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Dye Reagents
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
