Download Files:
Dexmedetomidine
$50 – $130
Products Details
Product Description
– Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3].
Web ID
– HY-12719
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C13H16N2
Citations
– Biomed Pharmacother. 2023 Nov 23:169:115915.|Cardiovasc Drugs Ther. 2023 Jul 1.|J Neuropathol Exp Neurol. 2022 Jul 11;nlac055.|J Toxicol Sci. 2023;48(3):139-148.|Molecular Cellular Toxicology. 2023 Jun 2.|Eur J Neurosci. 2021 Nov 4.|Hum Exp Toxicol. 2021 Dec;40(12):2145-2155.|Nat Commun. 2023 Jul 7;14(1):4011.|Pharmacology. 2021 Oct 29;1-14.
References
– [1]Virtanen R, et, al. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1988 May 20;150(1-2):9-14.|[2]Gertler R, et, al. Dexmedetomidine: a novel sedative-analgesic agent. Proc (Bayl Univ Med Cent). 2001 Jan;14(1):13-21.|[3]Sajid B, et, al. A comparison of oral dexmedetomidine and oral midazolam as premedicants in children. J Anaesthesiol Clin Pharmacol. Jan-Mar 2019;35(1):36-40.
CAS Number
– 113775-47-6
Molecular Weight
– 200.28
Compound Purity
– 99.93
SMILES
– C[C@H](C1=CN=CN1)C2=CC=CC(C)=C2C
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Adrenergic Receptor
Isoform
– α adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
