Desmorpholinyl Quizartinib-PEG2-COOH
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Desmorpholinyl Quizartinib-PEG2-COOH

SKU T39818-50 mg Category Brand:

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Products Details

Product Description

– Desmorpholinyl Quizartinib-PEG2-COOH is a compound featuring an FLT-3 ligand and a PEG-based PROTAC linker. It is employed in the synthesis of PROTAC FLT-3 degrader 1, which serves as a degrader for the FLT-3 internal tandem duplication (ITD) through PROTAC technology. The degrader exhibits an IC50 of 0.6 nM.

Web ID

– T39818

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C30H33N5O7S

References

– Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.

CAS Number

– 2292116-14-2

Molecular Weight

– C30H33N5O7S

SMILES

– CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCOCCOCCC(O)=O)ccc32)no1

Pathway

– Others

Product type

– PROTAC

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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