Download Files:
Desipramine (hydrochloride)
$60 – $96
Products Details
Product Description
– Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.
Web ID
– HY-B1272
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H23ClN2
Citations
– Biochim Biophys Acta Mol Basis Dis. 2023 Mar 28;1869(5):166700.|Glia. 2022 Jul 1.|Inflammation. 2021 Mar 4.|J Parkinson Dis. 2020;10(2):523-542.|Neural Regen Res. 2021;16:1660-70.|Neurotoxicology. 2022 Oct 6;S0161-813X(22)00156-5.|Parkinsons Dis-us. 2022.|Pharmaceutics. 2022, 14(8), 1523.|Research Square Print. 2023 Feb 23.
References
– [1]Torres GE, et al. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci. 2003 Jan;4(1):13-25.|[2]Zhao Z, et al. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology. 2008 Dec;33(13):3190-200.
CAS Number
– 58-28-6
Molecular Weight
– 302.84
Compound Purity
– 99.92
SMILES
– CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31.[H]Cl
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)
Target
– Dopamine Transporter;Serotonin Transporter
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
