Download Files:
Defactinib (hydrochloride)
$84 – $420
Products Details
Product Description
– Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
Web ID
– HY-12289A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H22ClF3N8O3S
Citations
– Bioact Mater. 1 July 2021.|Bioact Mater. 2021 Jun 1.|bioRxiv. 2023 Mar 2.|Mater Sci Eng C Mater Biol Appl. 2020 Jan;106:110221.|Mol Metab. 2023 Feb 24;101698.|Research Square Preprint. 2020 Jun.|Research Square Preprint. 2021 Aug.|ACS Nano. 2023 Jan 4.|Bone. 2021 Oct 12;116231.|Cell Death Dis. 2021 Sep 23;12(10):868.|Cell Mol Gastroenterol Hepatol. 2021;11(3):683-696.|Exp Cell Res. 12 October 2021, 112868.|Exp Ther Med. 2020 Aug;20(2):1405-1414.|Front Oncol. 2022 Apr 28;12:851065.|J Exp Clin Cancer Res. 2018 Jul 28;37(1):175.|J Exp Clin Cancer Res. 2022 Sep 16;41(1):275.|J Int Med Res. 2018 Apr;46(4):1311-1325. |J Orthop Transl. 2020 May 19;24:12-22.|J Transl Med. 2023 Sep 19;21(1):640.|Mol Carcinog. 2023 Oct 3.|Nat Commun. 2023 Apr 29;14(1):2478.|Nat Commun. 2019 Aug 16;10(1):3708. |Oncogene. 2023 Feb 23.|Phytomedicine. 21 July 2022, 154349.|Research Square Print. September 13th, 2022.|Sci Rep. 2019 May 20;9(1):7617.|Science. 2017 Dec 1;358(6367):eaan4368.|University of Zürich. Department of Dermatology. 2021 Dec.
References
– [1]Kang Y, et al. Role of focal adhesion kinase in regulating YB-1-mediated resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95.
CAS Number
– 1073160-26-5
Molecular Weight
– 546.95
Compound Purity
– 98.95
SMILES
– O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(=O)(C)=O)=N2)C=C1.[H]Cl
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : ≥ 25 mg/mL|H2O : 0.1 mg/mL (ultrasonic)
Target
– FAK
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
