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Defactinib
Price range: 50 CAD through 227 CAD
Products Details
Product Description
– Defactinib (VS-6063) is a second-generation inhibitor of FAK that inhibits FAK phosphorylation at the Tyr397 site. Defactinib has potential antitumor activity.
Web ID
– T1996
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C20H21F3N8O3S
Citations
– 1. Su Y, Li R, Ning X, et al. Discovery of 2, 4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel FAK inhibitors with antitumor and anti-angiogenesis activities. European Journal of Medicinal Chemistry. 2019 May 18;177:32-46
2. Li R, Gong L, Sun J, et al.Discovery of 2, 4-diarylaminopyrimidine derivatives bearing sulfonamide moiety as novel FAK inhibitors.Bioorganic Chemistry.2024: 107134.
References
– Kang Y, et al. J Natl Cancer Inst. 2013, 105(19), 1485-1495.
CAS Number
– 1073154-85-4
Molecular Weight
– C20H21F3N8O3S
Compound Purity
– 0.9913
SMILES
– CNC(=O)c1ccc(Nc2ncc(c(NCc3nccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Target
– Others
Pathway
– Angiogenesis|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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