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DDO-7263
Price range: 67 CAD through 555 CAD
Products Details
Product Description
– DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 is a potent Nrf2 activator that activates the Nrf2-ARE signaling pathway and exerts anti-inflammatory activity [1].
Web ID
– T60487
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C14H9F2N3O
References
– Xu LL, et al. 5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson’s disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress. Free Radic Biol Med. 2019 Apr;134:288-303.
CAS Number
– 2254004-96-9
Molecular Weight
– C14H9F2N3O
Compound Purity
– 0.9975
SMILES
– Cc1ccc(cn1)-c1noc(n1)-c1ccc(F)c(F)c1
Pathway
– Immunology/Inflammation
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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