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DC260126
SKU
HY-101906-10 mg
Category Reference compound
Tags Apoptosis;Free Fatty Acid Receptor, Apoptosis;GPCR/G Protein, Metabolic Disease
$60 – $528
Products Details
Product Description
– DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively)[1]. DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis[2].
Web ID
– HY-101906
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C16H18FNO2S
References
– [1]Hu H, et al. A novel class of antagonists for the FFAs receptor GPR40. Biochem Biophys Res Commun. 2009;390(3):557-563.|[2]Wu J, et al. Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis [published correction appears in J Cell Biochem. 2013 May;114(5):1216]. J Cell Biochem. 2012;113(4):1152-1158.
CAS Number
– 346692-04-4
Molecular Weight
– 307.38
Compound Purity
– 99.74
SMILES
– O=S(C1=CC=C(F)C=C1)(NC2=CC=C(CCCC)C=C2)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : ≥ 100 mg/mL
Target
– Apoptosis;Free Fatty Acid Receptor
Pathway
– Apoptosis;GPCR/G Protein
Product type
– Reference compound
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