Download Files:
Davunetide
$60 – $280
Products Details
Product Description
– Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity[1][2][3].
Web ID
– HY-105066
Storage Temperature
– -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C36H60N10O12
References
– [1]Quraishe S, et al. NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy. Mol Psychiatry. 2013;18(7):834-842.|[2]Zhang J, et al. Davunetide improves spatial learning and memory in Alzheimer’s disease-associated rats. Physiol Behav. 2017;174:67-73.|[3]Idan-Feldman A, et al. Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model. Neurobiol Dis. 2011;44(3):327-339.
CAS Number
– 211439-12-2
Molecular Weight
– 824.92
Compound Purity
– 99.86
SMILES
– O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CCC(N)=O)=O)[C@H]([C@@H](C)CC)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CCC2)N2C([C@H](C)NC([C@@H](N)CC(N)=O)=O)=O)=O)=O)=O
Clinical Information
– Phase 3
Research Area
– Neurological Disease
Solubility
– DMSO : 125 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Target
– Amyloid-β;Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Neuronal Signaling
Product type
– Peptides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
