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Dasatinib monohydrate
Price range: 53 CAD through 170 CAD
Products Details
Product Description
– Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activities of these kinases. Apparently, because of its less stringent binding affinity for the BCR-ABL kinase, Dasatinib monohydrate has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations.
Web ID
– T1448L
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H28ClN7O3S
Citations
– 1. Hu M M, He W R, Gao P, et al Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity. Cell Research. 2019, 29(3): 193-205
References
– O’Hare T, et al. Cancer Res. 2005, 65(11), 4500-4505.
CAS Number
– 863127-77-9
Molecular Weight
– C22H28ClN7O3S
Compound Purity
– 0.9989
SMILES
– n1cc(sc1Nc1nc(nc(N2CCN(CC2)CCO)c1)C)C(=O)Nc1c(cccc1C)Cl.O
Target
– Others
Pathway
– Autophagy|||Angiogenesis|||Cytoskeletal Signaling|||Apoptosis|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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