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Darovasertib
$88 – $1,012
Products Details
Product Description
– Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. Darovasertib has the potential for uveal melanoma research[1][2].
Web ID
– HY-101569
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H23F3N8O
References
– [1]Protein Kinase C Inhibitor LXS196|[2]US20180179181.
CAS Number
– 1874276-76-2
Molecular Weight
– 472.47
Compound Purity
– 99.42
SMILES
– NC1=C(C(NC2=C(N3CCC(C)(N)CC3)C=CC=N2)=O)N=C(C4=NC=CC=C4C(F)(F)F)C=N1
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : 25 mg/mL (ultrasonic)
Target
– PKC
Isoform
– PKCα;PKCθ
Pathway
– Epigenetics;TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
