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Daminozide
$50 – $96
Products Details
Product Description
– Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested[1][2].
Web ID
– HY-13643
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C6H12N2O3
References
– [1]Rose NR, Woon EC, Tumber A, Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43.|[2]Roy SS, et, al. Exploration of teratogenic and genotoxic effects of fruit ripening retardant Alar (Daminozide) on model organism Drosophila melanogaster. Interdiscip Toxicol. 2018 May;11(1):27-37.
CAS Number
– 1596-84-5
Molecular Weight
– 160.17
Compound Purity
– 98.0
SMILES
– O=C(NN(C)C)CCC(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 106.67 mg/mL (warming)|H2O : 100 mg/mL (ultrasonic)
Target
– Histone Demethylase
Isoform
– KDM2
Pathway
– Epigenetics
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
