Dacomitinib
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Dacomitinib

SKU T2483-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 51 CAD through 1,230 CAD

Products Details

Product Description

– Dacomitinib (PF299)(PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.

Web ID

– T2483

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C24H25ClFN5O2

Citations

– 1. Fujimura T, Furugaki K, Mizuta H, et al.Targeting ErbB and tankyrase1/2 prevent the emergence of drug-tolerant persister cells in ALK-positive lung cancer.npj Precision Oncology.2024, 8(1): 1-16.

References

– Engelman JA, et al, Cancer Res, 2007, 67(24), 11924-11932.

CAS Number

– 1110813-31-4

Molecular Weight

– C24H25ClFN5O2

Compound Purity

– 0.9972

SMILES

– COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=CCN1CCCCC1

Pathway

– Apoptosis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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