Dabrafenib
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Dabrafenib

SKU T1903-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 66 CAD through 253 CAD

Products Details

Product Description

– Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive. Dabrafenib exhibits antitumor activity for the treatment of B-RafV600E-mutated melanoma.

Web ID

– T1903

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C23H20F3N5O2S2

Citations

– 1. Alhaddad H, Ospina O E, Khaled M L, et al.Spatial transcriptomics analysis identifies a tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease.Cell Reports Medicine.2024 2. Qin X, Fu L, Li C, et al.Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling.Science China Life Sciences.2025: 1-15.

References

– King AJ, et al. Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions. PLoS One. 2013 Jul 3;8(7):e67583.

CAS Number

– 1195765-45-7

Molecular Weight

– C23H20F3N5O2S2

Compound Purity

– 0.9989

SMILES

– CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F

Target

– Antibacterial

Pathway

– MAPK

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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