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Products Details
Product Description
– CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target (CYP51/PD-L1) inhibitor, with IC50 values of 0.17 and 0.021 μM, respectively. CYP51/PD-L1-IN-4 exhibits excellent antifungal and antidrug-resistant fungal activity in vitro. CYP51/PD-L1-IN-4 can be used for fungal infections research[1].
Web ID
– HY-149617
Shipping
– Room temperature
Molecular Formula
– C27H28N4O3
References
– [1]Liu Y, et al. Construction and Evaluation of Novel Dual-function Antifungal Inhibitors and Covalent Organic Framework Carriers Based on the Infection Microenvironment. J Med Chem. 2023 Oct 12;66(19):13838-13857.
Molecular Weight
– 456.54
SMILES
– CC1=C(C2=CC=CC=C2)C=CC=C1COC3=CC=CC(CN[C@@](CN4N=CN=C4)(C(OC)=O)[H])=C3
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Cytochrome P450;PD-1/PD-L1
Isoform
– CYP51
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
