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Products Details
Product Description
– CXCR4 antagonist 4 is a potent, orally active CXCR4 antagonist (IC50=24 nM) with diminished CYP 2D6 activity, improved PAMPA permeability, potent inhibition of human immunodeficiency virus entry (IC50=7 nM)[1].
Web ID
– HY-144285
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C29H41F2N5
References
– [1]Jecs E, et al. Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles. J Med Chem. 2022, 65(5):4058-4084.
CAS Number
– 2761009-30-5
Molecular Weight
– 497.67
SMILES
– FC1(F)CCC(N(CCCCN([C@@H]2C3=NC=CC=C3CCC2)C[C@@H]4NCC5=C(C4)N=CC=C5)C)CC1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– CXCR;HIV
Isoform
– CXCR4;HIV
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation
Product type
– Peptides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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