Products Details

Product Description

– CXCR2 antagonist 7 (compound 19) is a potent CXCR2 antagonist. CXCR2 antagonist 7 shows potent CXCR2 binding affinity (IC50=0.044 µM) and calcium mobilization (IC50=0.66 µM)[ 1].

Web ID

– HY-144784

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C14H14F2N6OS

References

– [1]Van Hoof M, et al. Identification of novel chemotypes as CXCR2 antagonists via a scaffold hopping approach from a thiazolo[4,5-d]pyrimidine. Eur J Med Chem. 2022; 235:114268.

Molecular Weight

– 352.36

SMILES

– C[C@@H](NC1=C2N=NNC2=NC(SCC3=CC=CC(F)=C3F)=N1)CO

Clinical Information

– No Development Reported

Research Area

– Cancer; Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– CXCR

Isoform

– CXCR2

Pathway

– GPCR/G Protein;Immunology/Inflammation

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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