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Products Details
Product Description
– CV-159 is a unique dihydropyridine Ca2+ antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities.
Web ID
– HY-19025
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C31H34N4O7
References
– [1]Usui T, et al. Mechanisms underlying the anti-inflammatory effects of the Ca2+/calmodulin antagonist CV-159 in cultured vascular smooth muscle cells. J Pharmacol Sci. 2010;113(3):214-23. Epub 2010 Jun 16.|[2]Usui T, et al. CV-159, a unique dihydropyridine derivative, prevents TNF-induced inflammatory responses in human umbilical vein endothelial cells. J Pharmacol Sci. 2010;113(2):182-91. Epub 2010 May 19.|[3]Miyazaki H, et al. Neuroprotective effects of a dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbox ylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (CV-159), on rat ischemic brain injury. Life Sci. 1999;64(10):869-78.
CAS Number
– 86384-98-7
Molecular Weight
– 574.62
SMILES
– O=C(C1=C(C)NC(C)=C(C(OCCCCCCOC2=NNC(C3=CC=CC=C3)=C2)=O)C1C4=CC=CC([N+]([O-])=O)=C4)OC
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Calmodulin
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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