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Products Details
Product Description
– CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with Ki values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 Free base (CS-003) has therapeutic efficacy on respiratory diseases associated with neurokinins.
Web ID
– HY-19633
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C34H38Cl2N2O6S
References
– [1]Tsuchida H, et al. Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses. Eur J Pharmacol. 2008 May 31;586(1-3):306-12.
CAS Number
– 191672-52-3
Molecular Weight
– 673.65
SMILES
– O=C(N1C[C@@](CCN2CCC3(CC2)C4=CC=CC=C4C[S@@]3=O)(C5=CC=C(Cl)C(Cl)=C5)OCC1)C6=CC(OC)=C(OC)C(OC)=C6
Clinical Information
– No Development Reported
Research Area
– Infection; Endocrinology
Solubility
– 10 mM in DMSO
Target
– Neurokinin Receptor
Isoform
– NK1;NK2;NK3
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
