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Products Details
Product Description
– CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with Ki values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 Free base (CS-003) has therapeutic efficacy on respiratory diseases associated with neurokinins.
Web ID
– HY-19633
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C34H38Cl2N2O6S
References
– [1]Tsuchida H, et al. Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses. Eur J Pharmacol. 2008 May 31;586(1-3):306-12.
CAS Number
– 191672-52-3
Molecular Weight
– 673.65
SMILES
– O=C(N1C[C@@](CCN2CCC3(CC2)C4=CC=CC=C4C[S@@]3=O)(C5=CC=C(Cl)C(Cl)=C5)OCC1)C6=CC(OC)=C(OC)C(OC)=C6
Clinical Information
– No Development Reported
Research Area
– Infection; Endocrinology
Solubility
– 10 mM in DMSO
Target
– Neurokinin Receptor
Isoform
– NK1;NK2;NK3
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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