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Products Details
Product Description
– CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1].
Web ID
– HY-18713A
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C24H26ClN5S
References
– [1]Kjær S, et al. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J. 2013 Apr 15;451(2):329-42.
CAS Number
– 2250019-91-9
Molecular Weight
– 452.01
SMILES
– N[C@H](CNC1=NC(C2=CC=NC=C2)=NC3=C1C(CCCC4)=C4S3)CC5=CC=CC=C5.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– PKC;ROCK
Isoform
– PKCζ;PKC-ι ℩;ROCK2
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics;Stem Cell/Wnt;TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
