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Crenigacestat
Price range: 90 CAD through 595 CAD
Products Details
Product Description
– Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most tumor cell lines tested. It effectively inhibits mutant Notch receptor activity and, in a xenograft tumor model, inhibits the expression of Notch-regulated genes and N1ICD cleavage in the tumor microenvironment.
Web ID
– T3633
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H23F3N4O4
Citations
– 1. Lu B, He Y, He J, et al. Epigenetic profiling identifies LIF as a super-enhancer controlled regulator of stem cell-like properties in osteosarcoma. Molecular Cancer Research. 2020, 18(1): 57-67
References
– Eli Lilly Company. The 8th SCI-RSC Symposium on Proteinase Inhibitor Design. 2013.
CAS Number
– 1421438-81-4
Molecular Weight
– C22H23F3N4O4
Compound Purity
– 0.9736
SMILES
– C[C@H](NC(=O)CCC(F)(F)F)C(=O)N[C@H]1c2ccccc2-c2cccnc2N(CCO)C1=O
Target
– Others
Pathway
– Neuroscience|||Stem Cells|||Proteases/Proteasome
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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