Download Files:
CPI-637
$96 – $720
Products Details
Product Description
– CPI-637 is a selective and potent CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM, 0.051 μM and 11.0 μM for CBP, EP300 and BRD4 BD-1, respectively, and an EC50 of 0.3 μM for CBP[1].
Web ID
– HY-100482
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H22N6O
References
– [1]Taylor AM, et al. Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). ACS Med Chem Lett. 2016 Mar 15;7(5):531-6.
CAS Number
– 1884712-47-3
Molecular Weight
– 386.45
Compound Purity
– 99.94
SMILES
– O=C1NC2=CC=CC(C3=CC4=C(N(C)N=C4C5=CN(C)N=C5)C=C3)=C2N[C@H](C)C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 9.62 mg/mL (ultrasonic)
Target
– Epigenetic Reader Domain;Histone Acetyltransferase
Isoform
– BRD4;CBP/p300;TIP60
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
