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Products Details
Product Description
– Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3].
Web ID
– HY-N2573
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H23NO4
References
– [1]S Ameer Basha, et al. Effect of 1-corydalmine, an Alkaloid Isolated From <i>Corydalis Chaerophylla</i> Roots on Spore Germination of Some Fungi. Mycobiology. 2007 Jun;35(2):69-71.|[2]Xiange Tang, et al. In Vitro Metabolism of L-Corydalmine, a Potent Analgesic Drug, in Human, Cynomolgus Monkey, Beagle Dog, Rat and Mouse Liver Microsomes. J Pharm Biomed Anal. 2016 Sep 5;128:98-105.|[3]Lin Zhou, et al. Levo-corydalmine Alleviates Vincristine-Induced Neuropathic Pain in Mice by Inhibiting an NF-kappa B-dependent CXCL1/CXCR2 Signaling Pathway. Neuropharmacology. 2018 Jun;135:34-47.
CAS Number
– 30413-84-4
Molecular Weight
– 341.40
SMILES
– OC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4[C@]3([H])C2)=C1OC
Clinical Information
– No Development Reported
Research Area
– Infection; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– CXCR;Fungal
Isoform
– CXCR2
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation
Product type
– Natural Products
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