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CMC2.24
SKU
HY-120793-10 mg
Category Reference compound
Tags Apoptosis;GPCR/G Protein;Metabolic Enzyme/Protease, Apoptosis;MMP;Ras, Cancer; Inflammation/Immunology
$300 – $2,350
Products Details
Product Description
– CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC50s ranging from 2.0-69 μM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis[1][2][3].
Web ID
– HY-120793
Storage Temperature
– -20°C (Powder, protect from light)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H21NO5
References
– [1]Mallangada NA, et al. A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras. Mol Carcinog. 2018;57(9):1130-1143.|[2]Zhou Y, et al. Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. J Mol Med (Berl). 2020;98(10):1479-1491.|[3]Zhang Y, et al. Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: a focus on chemically-modified curcumins. Curr Med Chem. 2012;19(25):4348-4358.
CAS Number
– 1255639-43-0
Molecular Weight
– 427.45
Compound Purity
– 96.48
SMILES
– O=C(NC1=CC=CC=C1)C(C(/C=C/C2=CC=C(O)C=C2)=O)C(/C=C/C3=CC=C(O)C=C3)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– DMSO : < 1 mg/mL
Target
– Apoptosis;MMP;Ras
Isoform
– MMP-1;MMP-12;MMP-13;MMP-14;MMP-2;MMP-3;MMP-7;MMP-8;MMP-9
Pathway
– Apoptosis;GPCR/G Protein;Metabolic Enzyme/Protease
Product type
– Reference compound
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