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Product Description
– Clemastine (HS-592) is a potent and orally active histamine receptor H1 antagonist. Clemastine is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects[1][2].
Web ID
– HY-B0298
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C21H26ClNO
Citations
– Methods Mol Biol. 2023;2683:103-111.|Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.|Cell Prolif. 2021 Jan;54(1):e12953.|Microbiol Spectr. 2022 Mar 2;e0054121.|Prog Neuropsychopharmacol Biol Psychiatry. 2023 Nov 28:110901.|Viruses. 2021 Jun 28;13(7):1255.
References
– [1]Clemastine. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; January 16, 2017.
CAS Number
– 15686-51-8
Molecular Weight
– 343.89
SMILES
– CN1[C@@H](CCO[C@](C2=CC=CC=C2)(C3=CC=C(Cl)C=C3)C)CCC1
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Histamine Receptor
Isoform
– H1 Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
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