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Product Description
– cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.)[1]. Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects[2]. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM[3].
Web ID
– HY-N0619A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H32O14
References
– [1]Mei M, et al. In vitro pharmacokinetic characterization of mulberroside A, the main polyhydroxylated stilbene in mulberry (<i>Morus alba</i> L.), and its bacterial metabolite oxyresveratrol in traditional oral use. J Agric Food Chem. 2012 Mar 7;60(9):2299-308.|[2]Wang CP, et al. Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion. J Neurosci Res. 2014 Jul;92(7):944-54.|[3]Kim JK, et al. Biotransformation of mulberroside A from Morus alba results in enhancement of tyrosinase inhibition. J Ind Microbiol Biotechnol. 2010 Jun;37(6):631-7.|[4]Cai-Ping Wang,et al. Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. Planta Med. 2011 May;77(8):786-94.
CAS Number
– 166734-06-1
Molecular Weight
– 568.52
SMILES
– OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC2=CC(/C=CC3=C(C=C(C=C3)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)O)=CC(O)=C2
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Interleukin Related;TNF Receptor;Tyrosinase
Isoform
– IL-1;IL-6
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Natural Products
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