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CHPG
$360
Only 1000 item(s) left in stock.
Products Details
Product Description
– CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways[2].
Web ID
– HY-101364
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C8H8ClNO3
References
– [1]Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO<sub>2</sub>-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52.|[2]Chen T, et al. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med. 2012 Apr;29(4):630-6.
CAS Number
– 170846-74-9
Molecular Weight
– 201.61
Compound Purity
– 99.0
SMILES
– O=C(O)C(N)C1=CC(O)=CC=C1Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Cardiovascular Disease
Solubility
– 1M NaOH : 25 mg/mL (ultrasonic;adjust pH to 11 with NaOH)|DMSO : 1 mg/mL (ultrasonic)
Target
– Akt;ERK;mGluR;NF-κB
Isoform
– ERK;mGluR5;NF-κB
Pathway
– GPCR/G Protein;MAPK/ERK Pathway;Neuronal Signaling;NF-κB;PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
