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Chembridge-5861528
SKU
HY-15065-10 mg
Category Reference compound
Tags Membrane Transporter/Ion Channel;Neuronal Signaling, Metabolic Disease; Inflammation/Immunology; Neurological Disease, TRP Channel
$79 – $924
Products Details
Product Description
– Chembridge-5861528 (TCS 5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. Chembridge-5861528 shows antihypersensitivity activities[1].
Web ID
– HY-15065
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C19H23N5O3
References
– [1]Wei H, et al. Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology. 2009 Jul;111(1):147-54.|[2]Wei H, et al. Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat. Neurosci Lett. 2010 Aug 2;479(3):253-6.
CAS Number
– 332117-28-9
Molecular Weight
– 369.42
Compound Purity
– 99.76
SMILES
– O=C1C2=C(N=CN2CC(NC3=CC=C(C(C)CC)C=C3)=O)N(C)C(N1C)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 120 mg/mL (ultrasonic)
Target
– TRP Channel
Isoform
– TRPA
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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