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Product Description
– Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM[1]. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity[2]. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy[3][4].
Web ID
– HY-N2359
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H18NO4
Citations
– Cancer Cell Int. 2023 Jun 17;23(1):117.|Cell Commun Signal. 2021 Oct 11;19(1):103.|FASEB J. 2019 Dec;33(12):13644-13659.|Fishes. 2022, 7(5), 229.|Front Pharmacol. 13 May 2021.|Front Physiol. 2021 Oct 28;12:770430.|Harvard Medical School LINCS LIBRARY|J Headache Pain. 2022 Mar 8;23(1):35.|Phytother Res. 2023 Jul 4.|Research Square Preprint. 2020 Oct.|Sci Rep. 2017 Aug 23;7(1):9201.
References
– [1]Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9.|[2]Shi B, et al. Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats. Life Sci. 2019 Jan 1;216:85-91.|[3]Chan SL, et al.Identification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278(23):20453-6.|[4]Tang ZH, et al.Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Redox Biol. 2017 Aug;12:367-376.|[5]Li W, et al. Effect of chelerythrine against endotoxic shock in mice and its modulation of inflammatory mediators in peritoneal macrophages through the modulation of mitogen-activated protein kinase (MAPK) pathway. Inflammation. 2012 Dec;35(6):1814-24. |[6]He N, et al. Antibacterial mechanism of chelerythrine isolated from root of Toddalia asiatica (Linn) Lam. BMC Complement Altern Med. 2018 Sep 26;18(1):261.
CAS Number
– 34316-15-9
Molecular Weight
– 348.37
SMILES
– C[N+]1=CC2=C(OC)C(OC)=CC=C2C(C=CC3=C4)=C1C3=CC5=C4OCO5
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy;Bcl-2 Family;PKC
Isoform
– PKC
Pathway
– Apoptosis;Autophagy;Epigenetics;TGF-beta/Smad
Product type
– Natural Products
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