– Chalcones A-N-5, a trihydroxy chalcone derivative, exhibits no cytotoxicity at concentrations below 100 µM (with IC 50 > 1 mM) and notably enhances cell proliferation. It is particularly effective in encouraging neuronal cell growth within damaged brain tissue and demonstrates an ability to inhibit ferroptosis triggered by RSL or erastin, while also reducing lipid peroxidation levels associated with Aβ1-42 protein aggregation. Given these properties, Chalcones A-N-5 represents a promising molecular framework for further development as a lead compound in in vivo studies aimed at researching Alzheimer’s Disease (AD) [1].