Chalcones A-N-5

SKU HY-145858-Get quote Category Tags , ,

Products Details

Product Description

– Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC50 > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD[1].

Web ID

– HY-145858

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C21H20N4O4

References

– [1]Liu Y, et al. Rational design, synthesis and activities of hydroxylated chalcones as highly potent dual functional agents against Alzheimer’s disease. Bioorg Chem. 2022;122:105662.

CAS Number

– 2756846-09-8

Molecular Weight

– 392.41

SMILES

– CN(C1=NC=C(C=N1)NC2=CC=C(C=C2)/C=C/C(C3=C(C(O)=C(C=C3)O)O)=O)C

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Ferroptosis

Pathway

– Apoptosis

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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