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Chalcones A-N-5
Products Details
Product Description
– Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC50 > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD[1].
Web ID
– HY-145858
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H20N4O4
References
– [1]Liu Y, et al. Rational design, synthesis and activities of hydroxylated chalcones as highly potent dual functional agents against Alzheimer’s disease. Bioorg Chem. 2022;122:105662.
CAS Number
– 2756846-09-8
Molecular Weight
– 392.41
SMILES
– CN(C1=NC=C(C=N1)NC2=CC=C(C=C2)/C=C/C(C3=C(C(O)=C(C=C3)O)O)=O)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ferroptosis
Pathway
– Apoptosis
Product type
– Reference compound
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