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Cetuximab
Price range: 315 CAD through 3,168 CAD
Products Details
Product Description
– Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM). Cetuximab has antitumor activity, inhibiting tumor cell proliferation and inducing apoptosis.
Web ID
– T9905
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C107H179N35O36S7
Citations
– 1. Komatsu M, Nakamura K, Takeda T, et al. Aurora kinase blockade drives de novo addiction of cervical squamous cell carcinoma to druggable EGFR signalling. Oncogene. 2022: 1-14.
2. Li Y, Liu J, Huang J, et al.Reduced PTPRS expression promotes epithelial-mesenchymal transition of Schwann cells in NF1-related plexiform neurofibromas.Cancer Letters.2024: 217151.
3. Liu J, Liu Z, Zhao H, et al.Sequencing the Monoclonal Antibody Variable Regions Using Multiple Charge Integration Middle-Down Strategy and Ultraviolet Photodissociation.Analytica Chimica Acta.2024: 343450.
References
– Huang SM, et al. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res. 1999 Apr 15;59(8):1935-40.
CAS Number
– 205923-56-4
Molecular Weight
– C107H179N35O36S7
Compound Purity
– SDS-PAGE:98.4%；SEC-HPLC: 99.7%
Pathway
– JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors
Product type
– Inhibitory Antibodies
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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