Download Files:
Products Details
Product Description
– CDK8-IN-5 is a potent CDK8 inhibitor with an IC50 of 72 nM. CDK8-IN-5 shows anti-inflammatory activities with 43% IL-10 enhancement rate. CDK8-IN-5 has the potential for the research of inflammatory bowel disease[1].
Web ID
– HY-147527
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C26H22N2O4
References
– [1]Yan Y, et al. Discovery and Anti-Inflammatory Activity Evaluation of a Novel CDK8 Inhibitor through Upregulation of IL-10 for the Treatment of Inflammatory Bowel Disease In Vivo. J Med Chem. 2022 May 26;65(10):7334-7362.
CAS Number
– 2855087-10-2
Molecular Weight
– 426.46
SMILES
– O=C(C1=CC=C(C=C1)C2=CC(OC(C3=CC=CC=C3)=C4)=C(C(O)=C2)C4=O)N5CCNCC5
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– CDK
Isoform
– CDK8
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
