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CCT367766
Price range: 469 CAD through 3,168 CAD
Products Details
Product Description
– CCT367766 is a potent, PROTAC-based, third-generation, iso-functional pirin-targeted protein degradation probe (PDP) that depletes pirin expression at low concentrations.CCT367766 has an IC50 value of 490 nM for the CRBN-DDB1 complex.CCT367766 has a good affinity for recombinant pirin and CRBN. CCT367766 has a good affinity for recombinant pirin and CRBN, with Kd values of 55 nM and 120 nM, respectively. cct367766 is a potent orally active protein that reduces the expression of pirin at low concentrations.
Web ID
– T14908
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C49H48ClN7O11
References
– Chessum NEA, et al. Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).J Med Chem. 2018 Feb 8;61(3):918-933.
CAS Number
– 2229856-58-8
Molecular Weight
– C49H48ClN7O11
Compound Purity
– 0.9903
SMILES
– O=C(NC1=CC=C(Cl)C(=C1)NC(=O)C=2C=CC=3N=C(C=CC3C2)CN4CCN(CCOCCOCCOC5=CC=CC=6C(=O)N(C(=O)C56)C7C(=O)NC(=O)CC7)CC4)C8=CC=C9OCCOC9=C8
Target
– Others
Pathway
– PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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