CCR4 antagonist 3-1
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CCR4 antagonist 3-1

SKU T60336-1 mg Category Brand:

Price range: 149 CAD through 4,752 CAD

Products Details

Product Description

– CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM. CCR4 antagonist 3-1 inhibits the binding of radiolabeled [125I]TARC and macrophage-derived chemokine ( MDC) to CEM cell surface and inhibits TARC-mediated CEM cell migration in vitro with an IC50 value of 6.4 μM. CCR4 antagonist 3 inhibited the binding of radiolabeled [125I]TARC and macrophage-derived chemokine (MDC) to the CCR4 receptor on the surface of CEM cells and inhibited TARC-mediated migration of CEM cells in vitro with an IC50 value of 6.4 μM.

Web ID

– T60336

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C14H12N2S

References

– Wang X, et al. Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3.

CAS Number

– 1957-01-3

Molecular Weight

– C14H12N2S

Compound Purity

– 0.9953

SMILES

– N(C=1C2=C(C=CC1)C=CC=C2)C3=NC(C)=CS3

Pathway

– GPCR/G Protein|||Immunology/Inflammation|||Microbiology/Virology

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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